I always stay around midtown for work as office is there. It's easy to get around on subway wherever you stay,
I'm next over in September not for work but to see Oasis at the MetLife and have booked the Luma Hotel on 41st street. It was decently priced for dates we wanted, though I've not stayed there before.
I've stayed in various of the chains (often Hilton's) around Times Square as well as the Sofitel. Last time I stayed in the Soho Grand which is (unsurprisingly) in SoHo. It's decent and trendy area but not cheap. Prices can vary a lot in same hotel at different times. Best is to do non refundable and just to commit to the dates.